From small molecules to complex organelles

Latest News

January 7, 2025 WWTF Grant for Tim Clausen Tim Clausen (IMP) has secured funding from the Vienna Science & Technology Fund WWTF in the frame of their Life Sciences Call 2024. As coordinator of the project “Sounds of Silence – codons and chaperons in the protein folding concert” he teams up with the labs of Johannes Zuber (IMP) and Alex Bronstein (ISTA) to study how myosin, the protein responsible for muscle contraction, matures within cells. Read more →
December 23, 2024 Autophagy unveiled: The Dagdas Group is shining a light on cellular recycling The group of Yasin Dagdas at the GMI studies how selective autophagy detects and removes damaged or unwanted cellular structures. In 2024, the Dagdas group published four preprints describing essential features of selective autophagy. Read more →
December 17, 2024 Master’s Thesis opportunity in the Karagöz lab (Max Perutz Labs) The Karagöz Lab at the Max Perutz Labs is offering an opportunity for a Master’s thesis and is looking for a student interested in structural and biophysical approaches to reveal how ER chaperones regulate the UPR. Read more →

About the Program

Targeted Protein Degradation: From small molecules to complex organelles

Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy, and the crosstalk between them in the cytoplasm and in the nucleus. Furthermore, we investigate how small molecules can be used to chemically reprogram the degradation systems, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner …

Selected Publications

2024 Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion Science Advances Ferrari L, Bauer B, Qiu Y, Schuschnig M, Klotz S, Anrather D, Juretschke T, Beli P, Gelpi E, Martens S Go to publication →
2024 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells Science Offensperger F, Tin G, Duran-Frigola M, Hahn E, Dobner S, Ende CWA, Strohbach JW, Rukavina A, Brennsteiner V, Ogilvie K, Marella N, Kladnik K, Ciuffa R, Majmudar JD, Field SD, Bensimon A, Ferrari L, Ferrada E, Ng A, Zhang Z, Degliesposti G, Boeszoermenyi A, Martens S, Stanton R, Müller AC, Hannich JT, Hepworth D, Superti-Furga G, Kubicek S, Schenone M, Winter GE Go to publication →
2023 Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy Science Ehrmann JF, Grabarczyk DB, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, Shulkina A, Gogova R, Meinhart A, Versteeg GA, Clausen T Go to publication →

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