From small molecules to complex organelles
Latest News
- October 4, 2024 FWF Cluster of Excellence Grant awarded to consortium with participation from Noelia Urbán The Austrian Science Fund (FWF) has awarded a Cluster of Excellence Grant to “Neuronal Circuits in Health and Disease”, an interdisciplinary project co-coordinated by Noelia Urbán at IMBA. Read more →
- September 27, 2024 Collaborative postdoc position in the labs of Gijs Versteeg & Elif Karagöz The Versteeg and Karagöz labs at the Max Perutz Labs are looking for a shared full-time postdoctoral researcher to identify and study hitherto unknown degraders of endogenous mutators. Read more →
- September 27, 2024 Research technician for collaborative project in the Versteeg & Karagöz labs The Versteeg and Karagöz labs at the Max Perutz Labs are looking for a shared full-time research technician. The position is available immediately. Read more →
About the Program
Targeted Protein Degradation: From small molecules to complex organelles
Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy, and the crosstalk between them in the cytoplasm and in the nucleus. Furthermore, we investigate how small molecules can be used to chemically reprogram the degradation systems, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner …
Selected Publications
- 2024 Tau fibrils evade autophagy by excessive p62 coating and TAX1BP1 exclusion Science Advances Go to publication →
- 2023 Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy Science Go to publication →
- 2023 Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy EMBO Journal Go to publication →