Targeted Protein Degradation

The Groups: At the Dagdas Lab at the GMI, the goal is to employ a multidisciplinary approach to study the role of selective autophagy in cellular quality control at a cell type-specific resolution. The Proteomics Technology Hub of IMP, IMBA, and GMI, headed by Karl Mechtler, aims to develop new and powerful proteomic methods focusing on comprehensive strategies for in vivo crosslinking mass spectrometry and single cell proteomics.

 

The Project: Autophagy is a highly conserved quality control pathway that is involved in cellular reprogramming underlying development and stress tolerance. Despite recent advances in identification of the molecular players that carry out selective autophagic recycling processes, how autophagy tailors the proteome in different cell types remain unknown. Here, we will use single cell proteomics to dissect proteome remodeling via autophagy at cell type specific resolution.

Single-cell proteomics by mass spectrometry is emerging as a powerful and unbiased method for the investigation of cellular heterogeneity and thereby complementing transcriptomics and genomics data. Proteins are the main driver of cellular functionality and understanding their regulation is crucial to understand cellular development and pathogenesis.

 

This project is a collaborative effort of the Dagdas Group at the Gregor Mendel Institute and the Proteomics Technology Hub of IMP, IMBA and GMI, headed by Karl Mechtler

 

The Candidate: The successful candidate should hold a MSc degree in the fields of chemistry, biochemistry, molecular biology, or a related field. Experience in mass spectrometry as well as in the wet lab are desirable. Fluency in English is required, and English is used as working language. The candidate should be curious, creative, and excited about learning new topics and skills! Despite the emphasis on technology development, a candidate with experience, knowledge, or curiosity at the interception of analytical chemistry and biochemistry will make a perfect match.

 

The Environment: The successful candidate will work in the vibrant environment of the Vienna BioCenter – one of Europe’s largest science hubs with including four research institutes, three universities and ~24 biotech companies.

 

This 1-year predoc position can be extended to a PhD position associated with the Vienna BioCenter PhD program. The review of applications will begin on July 15th and will continue until the position is filled. The expected starting date is September 1st.

 

How to apply: Please send you application (motivation letter, CV, contact details of at least one reference) by mail to yasin.dagdas@gmi.oeaw.ac.at and karl.mechtler@imp.ac.at

 

This vacancy is listed in the Open Positions of the IMP (Ref2406)and the GMI, where you can also download the ad as pdf.