September 1, 2021
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
New work published in Nature Communications, from the team of Sascha Martens (University of Vienna) characterize the role of human cargo receptors in the selective autophagy of ubiquitin condensates.
Cargo receptors conduct the autophagic degradation of misfolded and ubiquitinated proteins. In this study, the group of Sascha Martens describe the human cargo receptors p62/SQSTM1, NBR1 and TAXBP1 in the selective autophagy of ubiquitinated substrates.
Publication:
Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig & Sascha Martens
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation
Nature Communications. September 1, 2021